Background

Anxiety and depression are a common issue in patients with cancer, yet understudied among hospitalized patients. The aim of this study was to estimate the prevalence of anxiety and depression symptomatology in cancer inpatients and its relationship with malnutrition.

Methods

Cross-sectional study in hospitalized cancer patients. A nutritional assessment was done using the Global Leadership Initiative on Malnutrition (GLIM) criteria to diagnose malnutrition. Data regarding anxiety and depression symptomatology was obtained with the Hospital Anxiety and Depression Scale (HADS).

Results

A total of 282 inpatients were assessed. GLIM criteria found 20% (66) of well-nourished and 80% (216) with malnutrition. HADS presented an average score of 8.3 ± 4.4 with respect to anxiety and an average score of 7.7 ± 4.6 with respect to depression. Up to 54% of the patients showed a possible presence of anxiety, and 45.3% of them showed a possible presence of depression. In malnourished patients, HADS score was non-significantly higher with respect to anxiety (8.5 ± 4.3 in malnourished vs 7.1 ± 4.6 in well-nourished; p = 0.06) and was significantly higher with respect to depression (8.2 ± 4.6 in malnourished vs 5.3 ± 4.0 in well-nourished; p < 0.001). After controlling for potential confounders, malnourished patients were 1.98 times more likely to present anxious symptomatology (95% CI 1.01–3.98; p = 0.049) and 6.29 times more likely to present depressive symptomatology (95% CI 1.73–20.47; p = 0.005).

Conclusions

The presence of anxiety and depression symptomatology in oncological inpatients is high. There is an association between malnutrition and presenting anxious and depressive symptomatology in hospitalized cancer patients.

中文翻译：

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癌症住院患者营养不良与焦虑抑郁症状出现的关系

背景

焦虑和抑郁是癌症患者的常见问题，但在住院患者中尚未得到充分研究。本研究的目的是估计癌症住院患者中焦虑和抑郁症状的患病率及其与营养不良的关系。

方法

住院癌症患者的横断面研究。使用全球营养不良领导倡议 (GLIM) 标准进行营养评估，以诊断营养不良。使用医院焦虑和抑郁量表 (HADS) 获得有关焦虑和抑郁症状的数据。

结果

共评估了 282 名住院患者。GLIM 标准发现 20% (66) 的人营养良好，80% (216) 的人营养不良。HADS 在焦虑方面的平均得分为 8.3 ± 4.4，在抑郁方面的平均得分为 7.7 ± 4.6。高达 54% 的患者表现出可能存在焦虑，其中 45.3% 表现出可能存在抑郁。在营养不良的患者中，HADS 评分在焦虑方面没有显着提高（营养不良为 8.5 ± 4.3，营养良好为 7.1 ± 4.6；p  = 0.06），而抑郁方面则显着更高（营养不良为 8.2 ± 4.6 vs 5.3 ± 4.0 in 营养良好；p < 0.001)。在控制潜在混杂因素后，营养不良患者出现焦虑症状的可能性增加 1.98 倍（95% CI 1.01-3.98；p  = 0.049），出现抑郁症状的可能性增加 6.29 倍（95% CI 1.73-20.47；p  = 0.005） .

结论

肿瘤住院患者存在焦虑和抑郁症状的比例很高。在住院癌症患者中，营养不良与呈现焦虑和抑郁症状之间存在关联。