NMR characterization of streptogramin B and L-156,587, a non-synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis,Magnetic Resonance in Chemistry

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NMR characterization of streptogramin B and L-156,587, a non-synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2021-09-21 , DOI: 10.1002/mrc.5219
Naoya Oku ₁ , Shion Takemura ₁ , Hiroyasu Onaka _{1,

2} , Yasuhiro Igarashi ₁

Affiliation

The complete ¹H and ¹³C NMR characterization of streptogramin B (1), the major component of a clinically important synergistic antibiotic complex, was presented for the first time, along with those of L-156,587 (2), a dehydrated congener of streptogramin A (3). Compounds 1 and 2 were not synergistic and produced by Streptomyces albogriseolus in co-culture with Tsukamurella pulmonis, which poses a question on the adaptive significance of the induced production of this antibiotic pair.

中文翻译：

链霉菌素 B 和 L-156,587 的核磁共振表征，链霉菌素家族抗生素复合物的非协同对由白链霉菌和肺冢菌联合培养诱导产生

首次展示了链霉素 B ( 1 )的完整¹ H 和¹³ C NMR 表征，该表征是临床上重要的协同抗生素复合物的主要成分，以及 L-156,587 ( 2 ) 的脱水同源物L-156,587 (2)一个（3）。化合物1和2没有协同作用，由白链霉菌与肺冢菌共培养产生，这对诱导产生这种抗生素对的适应性意义提出了一个问题。

更新日期：2021-09-21

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