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Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial.
American Heart Journal ( IF 3.7 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.ahj.2021.08.011
Anne H Tavenier 1 , Renicus S Hermanides 1 , Jan Paul Ottervanger 1 , Svetlana V Belitser 2 , Olaf H Klungel 2 , Arnoud W J van 't Hof 3 ,
Affiliation  

Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST-elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intravenous platelet inhibitors when patients vomit.

中文翻译:

呕吐对 ST 段抬高心肌梗死患者 P2Y12 血小板抑制的影响:ON-TIME 3 试验的预设亚组分析。

呕吐与 ST 段抬高型心肌梗死早期的替格瑞洛浓度降低和血小板反应性升高有关。这些结果支持在患者呕吐时重新加载替格瑞洛负荷剂量和/或使用静脉内血小板抑制剂治疗。
更新日期:2021-09-18
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