The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of ¹H and ¹³C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.

文章描述了细胞抑制剂[5-[[4,6-双(氮丙啶-1-基)-1,3,5-三嗪-2-基]氨基]-2,2-的生物相容性和生物活性的研究二甲基-1,3-二恶烷-5-基]甲醇（物质（a））。该化合物通过¹ H 和¹³碳谱、红外光谱、质谱。生物医学研究包括血液相容性研究（自发性溶血、血小板聚集、血浆凝固止血、与人血清白蛋白和 DNA 的结合）；抗氧化特性的测定（与 2,2-diphenyl-1-picrylhydrazyl 的反应、光致溶血、光动力特性、NO-自由基吸收）；基因毒性，以及使用 HEK-293、A549、PA-1、T98G、SK-HEP-1、PANC-1 细胞系的细胞毒性。该文章显示了物质 (a) 的细胞抑制作用的两种可能机制：由于其抗氧化活性和与 DNA 形成加合物的可能性。