Topical corticosteroids are the primary treatment of ocular inflammation caused by surgery, injury, or other conditions. Drug pre-corneal residence time, drug water solubility, and drug corneal permeability coefficient are the major factors that determine the ocular drug bioavailability after topical administration. Although growing research successfully enhanced local delivery of corticosteroids utilizing various strategies, rational and dynamic approaches to strategy selection are still lacking. Within this review, an overview of the various strategies as well as their performance in retention, solubility, and permeability coefficient of corticosteroids are provided. On this basis, the tradeoff of strategy selection is discussed, which may shed light on the rational choice and application of ophthalmic delivery enhancement strategies.

局部皮质类固醇是由手术、损伤或其他疾病引起的眼部炎症的主要治疗方法。药物在角膜前停留时间、药物水溶性和药物角膜渗透系数是决定局部给药后眼部药物生物利用度的主要因素。尽管越来越多的研究成功地利用各种策略增强了皮质类固醇的局部递送，但仍然缺乏合理和动态的策略选择方法。在这篇综述中，概述了各种策略及其在皮质类固醇的保留、溶解度和渗透系数方面的表现。在此基础上，探讨了策略选择的权衡，为眼科给药增强策略的合理选择和应用提供了启示。