Bilayer lipid vesicles (liposomes) composed of zwitter-ionic (electroneutral) egg yolk lecithin and anionic phosphatidylserine were loaded with a water-soluble antitumor antibiotic Dox and electrostatically adsorbed onto the surface of thermo-sensitive microgels synthesized from 3-(N,N-dimethylamino)propylmethacrylamide, N,N-methylenebisacrylamide and 2,2′-azobis(2-methylpropionamidine) dihydrochloride. The resulting saturated microgel-liposomes complex with ultimately adsorbed 40 liposomes retains encapsulated drug in water solution at 25 °C. An increase in temperature induces a collapse of the microgel core and squeezing of the liposome shell, followed by liposome disruption and a release of encapsulated Dox. An intensive Dox leakage begins when temperature reaches 39 °C; a maximum amount of Dox is released within 5 min after starting the temperature trigger. The results are of importance for constricting of thermo-sensitive drug carries and developing protocols for the most productive drug release.

由两性离子（电中性）蛋黄卵磷脂和阴离子磷脂酰丝氨酸组成的双层脂质囊泡（脂质体）负载水溶性抗肿瘤抗生素 Dox 并静电吸附到由 3-( N,N -二甲氨基）丙基甲基丙烯酰胺，N，N-亚甲基双丙烯酰胺和 2,2'-偶氮双（2-甲基丙脒）二盐酸盐。最终吸附了 40 个脂质体的饱和微凝胶-脂质体复合物在 25°C 的水溶液中保留了封装的药物。温度升高导致微凝胶核心塌陷和脂质体外壳挤压，随后脂质体破裂并释放封装的 Dox。当温度达到 39 °C 时，开始出现密集的 Dox 泄漏；启动温度触发后 5 分钟内释放最大量的 Dox。结果对于限制热敏药物携带和制定最有效的药物释放方案具有重要意义。