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Cocrystallization as a tool to stabilize liquid active ingredients
Crystallography Reviews ( IF 2.0 ) Pub Date : 2021-09-22 , DOI: 10.1080/0889311x.2021.1978079
Alessia Bacchi 1, 2 , Paolo Pio Mazzeo 1, 2
Affiliation  

Cocrystallization is an extensively used method in Crystal Engineering for tuning the properties of target compounds by pairing them with ad-hoc selected molecular partners (i.e. coformers) in a stoichiometric ratio within the same crystal structure. The formation of a new intermolecular network significantly alters the physical–chemical properties of the final material, becoming crucial for target applications such as pharmaceutical, agrochemical and nuctraceutical where cocrystals are largely investigated. Although, the majority of the cocrystals reported in the literature so far are generally made of coformers which are solid at room temperature, there is no restriction in using liquid or low melting compounds as a coformer. This contribution aims at reviewing some significant cases and applications where cocrystallization is used to stabilize liquid ingredients, that are generally poorly stable and their manufacturing, transportation, and storage conditions present considerable environmental, logistical, and cost-related challenges.



中文翻译:

共结晶作为稳定液体活性成分的工具

共结晶是晶体工程中广泛使用的方法,用于通过将目标化合物与ad-hoc配对来调整目标化合物的性质。在相同晶体结构内以化学计量比选择分子伙伴(即共形成物)。新分子间网络的形成显着改变了最终材料的物理化学性质,这对于主要研究共晶的药物、农用化学品和保健品等目标应用至关重要。尽管迄今为止文献中报道的大多数共晶通常由在室温下为固体的共形成物制成,但对于使用液体或低熔点化合物作为共形成物没有限制。这篇文章旨在回顾一些重要的案例和应用,在这些案例和应用中,共结晶用于稳定液体成分,这些成分通常稳定性较差,以及它们的制造、运输、

更新日期:2021-11-23
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