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Self-Assembly and Multifaceted Bioactivity of a Silver(I) Quinolinate Coordination Polymer
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2021-09-21 , DOI: 10.1021/acs.inorgchem.1c02110
Sabina W Jaros 1 , Agnieszka Krogul-Sobczak 2 , Barbara Bażanów 3 , Magdalena Florek 3 , Dominik Poradowski 4 , Dmytro S Nesterov 5 , Urszula Śliwińska-Hill 6 , Alexander M Kirillov 5, 7 , Piotr Smoleński 1
Affiliation  

Coordination polymers have emerged as a new class of potent biologically active agents due to a variety of important characteristics such as the presence of bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability. The research on intermediate metabolites has also been explored with implications toward the development of selective anticancer, antimicrobial, and antiviral therapeutic strategies. In particular, quinolinic acid (H2quin) is a recognized metabolite in kynurenine pathway and potent neurotoxic molecule, which has been selected in this study as a bioactive building block for assembling a new silver(I) coordination polymer, [Ag(Hquin)(μ-PTA)]n·H2O (1). This product has been prepared from silver oxide, H2quin, and 1,3,5-triaza-7-phosphaadamantane (PTA), and fully characterized by standard methods including single-crystal X-ray diffraction. Compound 1 has revealed distinctive bioactive features, namely (i) a remarkable antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus 36 (Ad-36), (ii) a significant antibacterial activity against clinically important bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and (iii) a selective cytotoxicity against HeLa (human cervix carcinoma) cell line. The present work widens a growing family of bioactive coordination polymers with potent antiviral, antibacterial, and antiproliferative activity.

中文翻译:


喹啉银配位聚合物的自组装和多方面生物活性



由于具有生物活性金属中心和连接基、低毒性、稳定性、可定制结构和生物利用度等多种重要特性,配位聚合物已成为一类新型有效的生物活性剂。中间代谢物的研究也对选择性抗癌、抗菌和抗病毒治疗策略的发展具有重要意义。特别是,喹啉酸 (H 2 quin) 是犬尿氨酸途径中公认的代谢物和强效神经毒性分子,在本研究中选择它作为组装新型银 (I) 配位聚合物 [Ag(Hquin) (μ-PTA)] n ·H 2 O( 1 )。该产品由氧化银、H 2 quin 和 1,3,5-三氮杂-7-磷金刚烷 (PTA) 制备而成,并通过包括单晶 X 射线衍射在内的标准方法进行了充分表征。化合物1具有独特的生物活性特征,即 (i) 对 1 型单纯疱疹病毒 (HSV-1) 和腺病毒 36 (Ad-36) 具有显着的抗病毒活性,(ii) 对临床重要细菌(金黄色葡萄球菌)具有显着的抗菌活性、大肠杆菌铜绿假单胞菌),以及 (iii) 针对 HeLa(人宫颈癌)细胞系的选择性细胞毒性。目前的工作扩大了一个不断增长的生物活性配位聚合物家族,具有有效的抗病毒、抗菌和抗增殖活性。
更新日期:2021-10-18
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