Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissue-mechanics, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell–cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease.

中文翻译：

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组织成熟度和机械状态在控制细胞挤压中的作用

上皮细胞通过挤压去除垂死或多余的细胞，这一过程可以无缝地将细胞挤出层外，而不会破坏它们的屏障功能。新的研究揭示了挤压、组织力学和发育之间的复杂关系。他们强调整个组织力学的重要性，而不是单个细胞力学在控制挤压方面的重要性。组织压实、硬度和细胞-细胞粘附会影响细胞挤出的效率和驱动它的机制，以适应发育或疾病期间的不同条件。