Breast cancer (BC) is a very common cancer among women and one of the primary causes of death in women worldwide. Because BC has different molecular subtypes, the challenges associated with targeted therapy have increased significantly, and the identification of new therapeutic targets has become increasingly urgent. Blocking apoptosis and inhibiting cell death are important characteristics of malignant tumours, including BC. Under adverse conditions, including exposure to antitumour therapy, inhibition of cell death programmes can promote cancerous transformation and the survival of cancer cells. Therefore, inducing cell death in cancer cells is fundamentally important and provides new opportunities for potential therapeutic interventions. Lytic forms of cell death, primarily pyroptosis, necroptosis and ferroptosis, are different from apoptosis owing to their characteristic lysis, that is, the production of cellular components, to guide beneficial immune responses, and the application of lytic cell death (LCD) in the field of tumour therapy has attracted considerable interest from researchers. The latest clinical research results confirm that lytic death signalling cascades involve the BC cell immune response and resistance to therapies used in clinical practice. In this review, we discuss the current knowledge regarding the various forms of LCD, placing a special emphasis on signalling pathways and their implications in BC, which may facilitate the development of novel and optimal strategies for the clinical treatment of BC.

中文翻译：

---

乳腺癌中受调节的溶解细胞死亡

乳腺癌 (BC) 是女性中非常常见的癌症，也是全球女性死亡的主要原因之一。由于 BC 具有不同的分子亚型，与靶向治疗相关的挑战显着增加，寻找新的治疗靶点变得越来越紧迫。阻断细胞凋亡和抑制细胞死亡是包括BC在内的恶性肿瘤的重要特征。在不利条件下，包括接受抗肿瘤治疗，抑制细胞死亡程序可以促进癌变和癌细胞的存活。因此，在癌细胞中诱导细胞死亡至关重要，并为潜在的治疗干预提供了新的机会。细胞死亡的溶解形式，主要是细胞焦亡、坏死性凋亡和铁死亡，裂解细胞死亡（LCD）在肿瘤治疗领域的应用引起了研究人员的极大兴趣。最新的临床研究结果证实，裂解性死亡信号级联反应涉及 BC 细胞免疫反应和对临床实践中使用的疗法的抗性。在这篇综述中，我们讨论了关于各种形式的 LCD 的当前知识，特别强调了信号通路及其在 BC 中的意义，这可能有助于为 BC 的临床治疗制定新的和最佳的策略。而裂解细胞死亡（LCD）在肿瘤治疗领域的应用引起了研究人员的极大兴趣。最新的临床研究结果证实，裂解性死亡信号级联反应涉及 BC 细胞免疫反应和对临床实践中使用的疗法的抗性。在这篇综述中，我们讨论了关于各种形式的 LCD 的当前知识，特别强调了信号通路及其在 BC 中的意义，这可能有助于为 BC 的临床治疗制定新的和最佳的策略。而裂解细胞死亡（LCD）在肿瘤治疗领域的应用引起了研究人员的极大兴趣。最新的临床研究结果证实，裂解性死亡信号级联反应涉及 BC 细胞免疫反应和对临床实践中使用的疗法的抗性。在这篇综述中，我们讨论了关于各种形式的 LCD 的当前知识，特别强调了信号通路及其在 BC 中的意义，这可能有助于为 BC 的临床治疗制定新的和最佳的策略。