In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-22 , DOI: 10.1002/anie.202111839
Ruo-Chen Guo _{1,

2} , Xue-Hao Zhang ₁ , Peng-Sheng Fan ₁ , Ben-Li Song ₁ , Zhi-Xiang Li ₁ , Zhong-Yu Duan ₂ , Zeng-Ying Qiao ₁ , Hao Wang ₁

Affiliation

An in vivo self-assembly strategy is developed to induce phase separation of cell membrane that improves the peptide drugs internalization and anticancer efficacy. KYp self-assembles in situ, which induces the aggregation of ALP and the protein-lipid phase separation and leakage on the cell membrane. The peptide drugs internalization is 2-fold enhanced compared to non-responsive peptide nanoparticle.