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Monodispersed Bioactive Glass Nanoclusters with Ultralarge Pores and Intrinsic Exceptionally High miRNA Loading for Efficiently Enhancing Bone Regeneration
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-09-22 , DOI: 10.1002/adhm.202101616
Yumeng Xue , Yi Guo , Meng Yu , Min Wang , Peter X. Ma , Bo Lei 1
Affiliation  

Adv. Healthcare Mater. 2017, 6, 1700630

DOI: 10.1002/adhm.201700630

In the original version of this paper, the caption for Figure 4 did not mention that 4B was reproduced from another paper. The correct Figure 4 caption should be:

Figure 4. Ultrahigh miRNA loading and protection capacity of BGNCs. Gel retardation pictures showing the miRNA binding ability of A) BGNCs and B) BGNs with different weight ratios to miRNA (2–64 mg µg−1). Reproduced with permission.[20] Copyright 2017, American Chemical Society. C) Quantitative miRNA loading efficiency of BGNC and BGN at 40 and 80 µg mL−1 (**p < 0.01, n = 5). D) Antinuclease degradation ability of various miRNA complexes after soaking in serum solution for 24 h. E) Quantitative miRNA intact percentage of different samples.

Furthermore, the H-E/Masson images for BGN and BGNC in Figure 9 were produced incorrectly. The correct Figure 9 is shown below:

image
Figure 9
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Histological analysis of new bone formation after 4 w implantation in defect site. H&E staining demonstrates the new bone formation (NB) dependent on various samples; Masson staining exhibits the collagen deposition (dark blue) in newly formed bone tissue. BGN@miRNA, BGNC, and BGNC@miRNA group significantly enhanced bone formation and collagen deposition in vivo.

The changes to Figure 9 do not affect the overall conclusions of this work.

[20] M. Yu, Y. Xue, P. X. Ma, C. Mao, B. Lei, ACS Appl. Mater. Interfaces 2017, 9, 8460.



中文翻译:

具有超大孔隙和内在异常高 miRNA 负载的单分散生物活性玻璃纳米团簇可有效增强骨再生

高级 医疗保健材料201761700630

DOI:10.1002/adhm.201700630

在这篇论文的原始版本中,图 4 的标题没有提到 4B 是从另一篇论文中复制的。正确的图 4 标题应该是:

图4。BGNCs的超高miRNA负载和保护能力。凝胶阻滞图片显示 A) BGNC 和 B) BGN 与 miRNA 的重量比不同 (2–64 mg µg -1 )的 miRNA 结合能力。经许可转载。[20]版权所有 2017,美国化学学会。C) BGNC 和 BGN 在 40 和 80 µg mL -1 时的定量 miRNA 加载效率(** p < 0.01,n = 5)。D) 在血清溶液中浸泡 24 小时后各种 miRNA 复合物的抗核酸酶降解能力。E) 不同样品的定量 miRNA 完整百分比。

此外,图 9 中 BGN 和 BGNC 的 HE/Masson 图像生成不正确。正确的图9如下所示:

图片
图 9
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在缺损部位植入 4 w 后新骨形成的组织学分析。H&E 染色表明新骨形成 (NB) 取决于各种样本;Masson 染色显示新形成的骨组织中的胶原沉积(深蓝色)。BGN@miRNA、BGNC和BGNC@miRNA组显着增强体内骨形成和胶原沉积。

对图 9 的更改不影响这项工作的总体结论。

[20] M. Yu, Y. Xue, PX Ma, C. Mao, B. Lei, ACS Appl. 母校。接口2017, 9, 8460。

更新日期:2021-09-22
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