Abstract

A new highly transformed sorbicillinoid derivative, trichoreesin A (1), and four known monomeric sorbicillinoids, sorbicillin (2), 2’,3’-dihydrosorbicillin (3), 3-demethylsorbicillin (4), and sohirnone A (5), were discovered from Trichoderma reesei Z56-8, an epiphyte from the marine brown alga Sargassum sp. The structure and relative configuration of 1 were determined by interpretation of UV, IR, NMR, and MS signals, and its absolute configuration was assigned by analysis of ECD data aided by quantum chemical calculations. This is the first survey of metabolites from marine algicolous T. reesei. Compound 1 represents the first bicyclic vertinolide derivative, and it possesses inhibition of several marine phytoplankton species.

摘要

一种新的高度转化的 sorbicillinoid 衍生物、trichoreesin A ( 1 ) 和四种已知的单体 sorbicillinoids、sorbicillin ( 2 )、2',3'-dihydrosorbicillin ( 3 )、3-demethylsorbicillin ( 4 ) 和 sohirnone A ( 5 )从里氏木霉Z56-8 中发现，这是一种来自海洋褐藻马尾藻的附生植物。1的结构和相对构型通过 UV、IR、NMR 和 MS 信号的解释确定，其绝对构型通过量子化学计算辅助的 ECD 数据分析指定。这是对海洋藻类里氏木霉代谢物的首次调查。化合物I代表第一个双环 vertinolide 衍生物，它对几种海洋浮游植物具有抑制作用。