The serrated pathway of carcinogenesis has been the subject of intense investigation over the past 2 decades, but many gaps in our understanding still need to be resolved. Serrated polyp precursors include hyperplastic polyps, sessile serrated polyps, and traditional serrated adenomas. These are considered discrete entities, but there is emerging molecular data to suggest that they may be more closely related to each other than currently believed. The recent US Multi-Society Task Force surveillance guidelines for patients with serrated polyps are admittedly based on low quality evidence. In this brief review, we discuss the limitations in endoscopic detection and pathologic interpretation of serrated polyps and the implications of these diagnostic difficulties on risk prediction and postpolypectomy surveillance recommendations.

中文翻译：

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锯齿状息肉的前沿。

在过去的 20 年里，锯齿状的致癌途径一直是深入研究的主题，但我们在理解上的许多差距仍然需要解决。锯齿状息肉前体包括增生性息肉、无蒂锯齿状息肉和传统的锯齿状腺瘤。这些被认为是离散的实体，但有新出现的分子数据表明它们之间的关系可能比目前认为的更密切。最近美国多社会工作组对锯齿状息肉患者的监测指南无疑是基于低质量的证据。在这篇简短的综述中，我们讨论了锯齿状息肉的内窥镜检测和病理学解释的局限性，以及这些诊断困难对风险预测和息肉切除术后监测建议的影响。