Frontiers in Genetics ( IF 2.8 ) Pub Date : 2021-09-22 , DOI: 10.3389/fgene.2021.703242 Davide Simone 1 , Alessia Stingo 1 , Francesco Ciccia 1
In Spondyloarthropathies (SpA), a common group of immune-mediated diseases characterised by excessive inflammation of musculo-skeletal structures and extra-articular organs, T helper 17 (Th17) cells are widely considered the main drivers of the disease. Th17 are able to modulate their genes according to the immune environment: upon differentiation, they can adopt either housekeeping, anti-bacterial gene modules or inflammatory, pathogenic functions, and only the latter would mediate immune diseases, such as SpA. Experimental work aimed at characterising Th17 heterogeneity is largely performed on murine cells, for which the
中文翻译:
脊柱关节病中 T 辅助 17 致病性的遗传和环境决定因素
脊柱关节病 (SpA) 是一组常见的以肌肉骨骼结构和关节外器官过度炎症为特征的免疫介导疾病,T 辅助 17 (Th17) 细胞被广泛认为是该疾病的主要驱动因素。Th17 能够根据免疫环境调节其基因:分化后,它们可以采用看家、抗菌基因模块或炎症、致病功能,只有后者才能介导免疫疾病,如 SpA。旨在表征 Th17 异质性的实验工作主要在鼠细胞上进行,为此