We studied the efficacy of using mesenchymal stem cells (MSC) and a polymeric compound (based on chitosan and cellulose with integrated cerium dioxide nanoparticles (PCCD)) in wound healing, and to compare the effects with various invasive and external drugs used for the same purpose. Two wounds were made on the backs of each of 112 Wistar rats, removing the skin. Eight groups were studied: Control_0—intact wounds; Control_ss—0.9% NaCl injections; MSC injections; Control_msc—intact wounds on the opposite side of the body from the MSC group; external application of the PCCD; external application of a combination of the drugs PCCD + MSC; DCh –ointment Dioxomethyltetrahydropyrimidine + Chloramphenicol; and DHCB—injections of a deproteinized hemoderivative of calf blood. After 14 days, we evaluated the state and size of the wounds, studied the level of microcirculation, performed a histological study, and identified and counted the different types of cells. The most effective remedy was combination PCCD + MSC. The treatments in the PCCD and MSC groups were more effective than in the DHCB and DCh groups. Invasive drugs and DCh slowed the regeneration process. DHCB did not affect the rate of healing for acute wounds without ischemia during the first week. The proven efficacy of developed polymeric compounds demonstrates the feasibility of further studies in clinical practice.

中文翻译：

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用间充质干细胞和生物聚合物组合物单独和联合治疗的急性皮肤伤口：药物疗效评价和愈合机制分析

我们研究了使用间充质干细胞 (MSC) 和聚合化合物（基于壳聚糖和纤维素与集成二氧化铈纳米粒子 (PCCD)）在伤口愈合中的功效，并比较了用于相同目的的各种侵入性和外用药物的效果。目的。在 112 只 Wistar 大鼠的每只背上划了两个伤口，去除了皮肤。研究了八组：Control_0——完整的伤口；Control_ss—0.9% NaCl 注射液；MSC 注射；Control_msc——MSC组身体另一侧的完整伤口；PCCD的外部应用；外用药物PCCD + MSC; DCh – 软膏二氧甲基四氢嘧啶 + 氯霉素；和 DHCB——注射小牛血的脱蛋白血液衍生物。14天后，我们评估伤口的状态和大小，研究了微循环水平，进行了组织学研究，并对不同类型的细胞进行了鉴定和计数。最有效的补救措施是组合 PCCD + MSC。PCCD 和 MSC 组的治疗比 DHCB 和 DCh 组更有效。侵入性药物和 DCh 减慢了再生过程。在第一周内，DHCB 不影响无缺血的急性伤口的愈合速度。已开发的聚合化合物经证实的功效证明了在临床实践中进一步研究的可行性。侵入性药物和 DCh 减慢了再生过程。在第一周内，DHCB 不影响无缺血的急性伤口的愈合速度。已开发的聚合化合物经证实的功效证明了在临床实践中进一步研究的可行性。侵入性药物和 DCh 减慢了再生过程。在第一周内，DHCB 不影响无缺血的急性伤口的愈合速度。已开发的聚合化合物经证实的功效证明了在临床实践中进一步研究的可行性。