The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2 vaccines in older adults has been very encouraging but the longevity of vaccine immunity is currently unknown and protection against emerging variants may be lower. Adoptive immunotherapy with neutralizing mAb may offer an alternative for poor vaccine responders, while the mechanisms underlying failure to respond are still unclear. Further studies of B and T cell responses and their regulation particularly in older populations will provide a more solid foundation to develop suitable approaches to optimize vaccine responses of older adults who fail to mount a durable response.

中文翻译：

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在“现实世界”环境中验证 SARS-CoV-2 疫苗对老年人的有效性


世界各地 SARS-CoV-2 疫苗接种的迅速开展大大减少了高度疫苗接种国家的 COVID-19 新病例数量及其严重程度。 SARS-CoV-2 疫苗对老年人的意想不到的功效非常令人鼓舞，但疫苗免疫力的寿命目前尚不清楚，而且对新出现变异的保护作用可能较低。使用中和单克隆抗体的过继免疫疗法可能为疫苗反应不佳的人提供一种替代方案，但未能做出反应的机制仍不清楚。对 B 和 T 细胞反应及其调节（特别是在老年人群中）的进一步研究将为开发合适的方法来优化未能产生持久反应的老年人的疫苗反应提供更坚实的基础。