Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions,Green Chemistry

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Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2021-09-01 , DOI: 10.1039/d1gc02449c
Dawei Cao _{1,

2,

3} , Shumei Xia ₃ , Pan Pan ₂ , Huiying Zeng ₂ , Chao-Jun Li ₃ , Yong Peng ₁

Affiliation

Alcohols are versatile structural motifs of pharmaceuticals, agrochemicals and fine chemicals. With respect to green chemistry, the development of more sustainable and cost-efficient processes for converting ketones/aldehydes to alcohols is highly desired. Herein, a direct light-driven strategy for reducing ketones/aldehydes to alcohols using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atmosphere at room temperature is developed. This operationally simple light-promoted Meerwein–Ponndorf–Verley (MPV) type reduction can be used to produce various benzylic alcohol derivatives as well as applied to bioactive molecules and PEEK model compounds, demonstrating its application potential.

中文翻译：

在温和条件下用异丙醇光驱动 MPV 型将芳基酮/醛还原为醇

醇是药物、农用化学品和精细化学品的多功能结构基序。在绿色化学方面，非常需要开发更可持续和更具成本效益的将酮/醛转化为醇的工艺。在此，开发了一种使用异丙醇作为还原剂和溶剂，在t- BuOLi存在下，在室温空气气氛下将酮/醛还原为醇的直接光驱动策略。这种操作简单的光促进 Meerwein-Ponndorf-Verley (MPV) 型还原可用于生产各种苯甲醇衍生物，也可应用于生物活性分子和 PEEK 模型化合物，展示了其应用潜力。

更新日期：2021-09-22

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