Recent advances in catalytic asymmetric aza-Cope rearrangement,Chemical Communications

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Recent advances in catalytic asymmetric aza-Cope rearrangement
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-07 , DOI: 10.1039/d1cc04387k
Liang Wei ₁ , Chun-Jiang Wang _{1,

2}

Affiliation

Aza-Cope rearrangement, as one of the fundamental reactions for C–C and C–N bond formation, has been extensively utilized for the rapid construction of synthetically challenging organic molecules. Despite significant achievements having been made in the past 80 years, catalytic enantioselective versions still remain a challenge, mainly due to the inherent nature of the reversibility of aza-Cope rearrangement. Recently, owing to the intensive development of asymmetric catalysis strategies, various chiral organocatalysts and transition-metal catalysts have been successfully applied to control the stereoselectivity of aza-Cope rearrangement, and remarkable advances have been achieved. This review highlights recent progress relating to catalytic asymmetric aza-Cope rearrangement and covers important features of these studies, including catalytic system design, mechanistic insights, stereochemistry analysis, and synthetic applications.

中文翻译：

催化不对称氮杂-科普重排的最新进展

Aza-Cope 重排作为 C-C 和 C-N 键形成的基本反应之一，已被广泛用于快速构建具有合成挑战性的有机分子。尽管在过去 80 年中取得了重大成就，但催化对映选择性版本仍然是一个挑战，这主要是由于 aza-Cope 重排可逆性的固有性质。近年来，由于不对称催化策略的深入发展，各种手性有机催化剂和过渡金属催化剂已成功应用于控制氮杂-科普重排的立体选择性，并取得了显着进展。本综述重点介绍了与催化不对称氮杂-科普重排相关的最新进展，并涵盖了这些研究的重要特征，

更新日期：2021-09-22

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