当前位置: X-MOL 学术Phys. Chem. Chem. Phys. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Understanding the molecular mechanisms of transcriptional bursting
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2021-09-16 , DOI: 10.1039/d1cp03665c
Alena Klindziuk 1 , Anatoly B Kolomeisky 2
Affiliation  

In recent years, it has been experimentally established that transcription, a fundamental biological process that involves the synthesis of messenger RNA molecules from DNA templates, does not proceed continuously as was expected. Rather, it exhibits a distinct dynamic behavior of alternating between productive phases when RNA molecules are actively synthesized and inactive phases when there is no RNA production at all. The bimodal transcriptional dynamics is now confirmed to be present in most living systems. This phenomenon is known as transcriptional bursting and it attracts significant amounts of attention from researchers in different fields. However, despite multiple experimental and theoretical investigations, the microscopic origin and biological functions of the transcriptional bursting remain unclear. Here we discuss the recent developments in uncovering the underlying molecular mechanisms of transcriptional bursting and our current understanding of them. Our analysis presents a physicochemical view of the processes that govern transcriptional bursting in living cells.

中文翻译:

了解转录爆发的分子机制

近年来,已经通过实验证实,转录是一种基本的生物学过程,涉及从 DNA 模板合成信使 RNA 分子,它不会像预期的那样连续进行。相反,它表现出一种独特的动态行为,即在活跃合成 RNA 分子时的生产阶段和根本不生产 RNA 时的非活性阶段之间交替。双峰转录动力学现在被证实存在于大多数生命系统中。这种现象被称为转录爆发,它引起了不同领域研究人员的大量关注。然而,尽管进行了多项实验和理论研究,转录爆发的微观起源和生物学功能仍不清楚。在这里,我们讨论了揭示转录爆发的潜在分子机制的最新进展以及我们目前对它们的理解。我们的分析提出了控制活细胞转录爆发过程的物理化学观点。
更新日期:2021-09-22
down
wechat
bug