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Electrospun Nylon Fibers with Integrated Polypyrrole Molecularly Imprinted Polymers for the Detection of Glucose
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-09-22 , DOI: 10.1021/acs.analchem.1c02472
Robert D Crapnell 1 , Ryan J Street 1 , Valentine Ferreira-Silva 2 , Michael P Down 1 , Marloes Peeters 3 , Craig E Banks 1
Affiliation  

Electrospun nylon 6,6 fibers incorporating polypyrrole (PPy) molecular-imprinted polymers (MIPs) were produced for the selective detection of d-glucose using a thermal detection methodology. PPy MIPs were produced using a facile bulk synthesis approach and electrospun into intricate fibrous scaffolds giving a highly mass-producible sensing interface. The maximum incorporation of MIPs and greatest sensing performance was found to be 12.1 wt % in conjunction with the heat-transfer method (HTM), a low-cost and simple thermal detection method that measures changes in the thermal resistance at the solid–liquid interface. It is demonstrated that a 12.1% incorporation of MIPs into electrospun fibers produces the widest working linear range with a limit of detection of 0.10 ± 0.01 mM. There were no observed changes in the measured thermal resistance response to incubation with a series of structurally similar compounds, providing evidence toward the selectivity of the platform. Additionally, the sensing platform exhibited a linear working response to glucose samples in artificial sweat solutions in the biologically relevant range. This is the first report of the incorporation of MIPs into nylon 6,6 fibers for the detection of glucose and points toward the possibility of developing mass-producible electrospun fibers embedded with low-cost recognition elements of improved thermal and chemical stability for the application of wearable sensor technology.

中文翻译:

用于检测葡萄糖的带有集成聚吡咯分子印迹聚合物的电纺尼龙纤维

生产包含聚吡咯 (PPy) 分子印迹聚合物 (MIP) 的电纺尼龙 6,6 纤维,用于选择性检测d-葡萄糖使用热检测方法。PPy MIP 是使用简便的批量合成方法生产的,并电纺成复杂的纤维支架,提供可大规模生产的传感界面。与传热法 (HTM) 相结合,发现 MIP 的最大结合和最大传感性能为 12.1 重量%,这是一种低成本且简单的热检测方法,可测量固液界面热阻的变化. 结果表明,将 12.1% 的 MIP 掺入电纺纤维可产生最宽的工作线性范围,检测限为 0.10 ± 0.01 mM。在与一系列结构相似的化合物孵育时,测量的热阻响应没有观察到变化,这为平台的选择性提供了证据。此外,传感平台对生物相关范围内人造汗液溶液中的葡萄糖样品表现出线性工作响应。这是首次将 MIP 掺入尼龙 6,6 纤维以检测葡萄糖的报告,并指出了开发嵌入低成本识别元素的可大规模生产的电纺纤维的可能性,这些识别元素具有改善的热和化学稳定性,用于应用可穿戴传感器技术。
更新日期:2021-10-06
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