Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to regulation of different cellular events that are necessary for maintaining physiological condition. Dysregulation of miRNAs is correlated with development of various pathological events such as neurological disorders, cardiovascular diseases, and cancer. miRNA-489 is a new emerging miRNA and studies are extensively investigating its role in pathological conditions. Herein, potential function of miRNA-489 as tumor-suppressor in various cancers is described. miRNA-489 is able to sensitize cancer cells into chemotherapy by disrupting molecular pathways involved in cancer growth such as PI3K/Akt, and induction of apoptosis. The PROX1 and SUZ12 as oncogenic pathways, are affected by miRNA-489 in suppressing metastasis of cancer cells. Wnt/β-catenin as an oncogenic factor ensuring growth and malignancy of tumors is inhibited via miRNA-489 function. For enhancing drug sensitivity of tumors, restoring miRNA-489 expression is a promising strategy. The lncRNAs can modulate miRNA-489 expression in tumors and studies about circRNA role in miRNA-489 modulation should be performed. The expression level of miRNA-489 is a diagnostic tool for tumor detection. Besides, down-regulation of miRNA-489 in tumors provides unfavorable prognosis.

最近，microRNA (miRNA) 已被证明是疾病治疗中潜在的治疗、诊断和预后靶点。这些内源性非编码 RNA 有助于调节维持生理状况所必需的不同细胞事件。miRNA 的失调与各种病理事件的发展有关，例如神经系统疾病、心血管疾病和癌症。miRNA-489 是一种新兴的 miRNA，研究正在广泛研究其在病理条件下的作用。在此，描述了 miRNA-489 在各种癌症中作为肿瘤抑制因子的潜在功能。miRNA-489 能够通过破坏参与癌症生长的分子途径（如 PI3K/Akt）和诱导细胞凋亡，使癌细胞对化疗敏感。PROX1 和 SUZ12 作为致癌途径，受 miRNA-489 影响抑制癌细胞的转移。Wnt/β-catenin 作为致癌因子，通过 miRNA-489 功能抑制肿瘤的生长和恶性。对于增强肿瘤的药物敏感性，恢复 miRNA-489 的表达是一个很有前景的策略。lncRNAs 可以调节肿瘤中 miRNA-489 的表达，应该对 circRNA 在 miRNA-489 调节中的作用进行研究。miRNA-489的表达水平是肿瘤检测的诊断工具。此外，肿瘤中miRNA-489的下调提供不利的预后。lncRNAs 可以调节肿瘤中 miRNA-489 的表达，应该对 circRNA 在 miRNA-489 调节中的作用进行研究。miRNA-489的表达水平是肿瘤检测的诊断工具。此外，肿瘤中miRNA-489的下调提供不利的预后。lncRNAs 可以调节肿瘤中 miRNA-489 的表达，应该对 circRNA 在 miRNA-489 调节中的作用进行研究。miRNA-489的表达水平是肿瘤检测的诊断工具。此外，肿瘤中miRNA-489的下调提供不利的预后。