Photo-cross-linked Gelatin Glycidyl Methacrylate/N-Vinylpyrrolidone Copolymeric Hydrogel with Tunable Mechanical Properties for Ocular Tissue Engineering Applications,ACS Applied Bio Materials

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Photo-cross-linked Gelatin Glycidyl Methacrylate/N-Vinylpyrrolidone Copolymeric Hydrogel with Tunable Mechanical Properties for Ocular Tissue Engineering Applications
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-09-21 , DOI: 10.1021/acsabm.1c00905
Sina Sharifi ₁ , Hannah Sharifi ₁ , Ali Akbari ₂ , Darrell Koza ₃ , Claes H Dohlman ₁ , Eleftherios I Paschalis ₁ , James Chodosh ₁

Affiliation

Corneal transplantation is currently the primary treatment for corneal blindness. However, severe global scarcity of donor corneas is driving the scientific community to find novel solutions. One potential solution is to replace the damaged tissue with a biocompatible artificial cornea. Here, gelatin glycidyl methacrylate (GM) and N-vinylpyrrolidone (VP) were cocrosslinked to afford a hybrid bicomponent copolymeric hydrogel with excellent mechanical, structural, and biological properties. Our studies showed that the GM/VP ratio can be adjusted to generate a construct with high tensile modulus and strength of 1.6 and 1.0 MPa, respectively, compared to 14 and 7.5 MPa for human cornea. The construct can tolerate up to 22.4 kPa pressure before retention sutures can tear through it. Due to the presence of a synthetic component, it has a significantly higher stability against collagenase induced degradation, yet it is biocompatible and promotes cellular adhesion, proliferation, and migration under in vitro settings.

中文翻译：

用于眼部组织工程应用的具有可调机械性能的光交联明胶甲基丙烯酸缩水甘油酯/N-乙烯基吡咯烷酮共聚物水凝胶

角膜移植是目前角膜失明的主要治疗方法。然而，全球供体角膜的严重短缺正在推动科学界寻找新的解决方案。一种潜在的解决方案是用生物相容性人工角膜替换受损组织。在这里，明胶甲基丙烯酸缩水甘油酯 (GM) 和N-乙烯基吡咯烷酮 (VP) 共交联，得到具有优异机械、结构和生物学性能的混合双组分共聚水凝胶。我们的研究表明，可以调整 GM/VP 比率以生成具有高拉伸模量和强度的结构，分别为 1.6 和 1.0 MPa，而人类角膜为 14 和 7.5 MPa。该构造可以承受高达 22.4 kPa 的压力，然后保留缝合线可以撕裂它。由于合成成分的存在，它对胶原酶诱导的降解具有显着更高的稳定性，但它具有生物相容性，并在体外环境下促进细胞粘附、增殖和迁移。

更新日期：2021-10-18

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