Widespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of the brain, and their clinical and psychological function have not been investigated yet in BD. 24 patients with BD type-I (BD-I), and 30 with BD type-II (BD-II), and 45 controls underwent MRI scan. Voxel-based morphometry and source-based morphometry (SBM) were performed to extract structural covariation patterns of GMV. SBM components associated with morphometric differences were compared among diagnoses. Executive function and emotional processing correlated with morphometric characteristics. Compared to controls, BD-I showed reduced GMV in the temporo-insular-parieto-occipital cortex and in the culmen. An SBM component spanning the prefrontal-temporal-occipital network exhibited significantly lower GMV in BD-I compared to controls, but not between the other groups. The structural network covariance in BD-I was associated with the number of previous manic episodes and with worse executive performance. Compared to BD-II, BD-I showed a loss of GMV in the temporal-occipital regions, and this was correlated with impaired emotional processing. Altered prefrontal-temporal-occipital network structure could reflect a neural signature associated with visuospatial processing and problem-solving impairments as well as emotional processing and illness severity in BD-I.

在双相情感障碍 (BD) 中报告了广泛的区域灰质体积 (GMV) 改变。结构网络被认为可以更好地反映大脑的复杂多变量组织，其临床和心理功能尚未在 BD 中进行研究。24 名 BD I 型 (BD-I) 患者和 30 名 BD II 型 (BD-II) 患者和 45 名对照者接受了 MRI 扫描。进行基于体素的形态测量和基于源的形态测量 (SBM) 以提取 GMV 的结构协变模式。在诊断之间比较与形态学差异相关的 SBM 成分。执行功能和情绪处理与形态特征相关。与对照组相比，BD-I 在颞-岛-顶-枕叶皮质和穹窿中的 GMV 降低。与对照组相比，跨越前额-颞-枕网络的 SBM 组件在 BD-I 中表现出显着较低的 GMV，但在其他组之间则没有。BD-I 中的结构网络协方差与先前躁狂发作的次数和较差的执行表现有关。与 BD-II 相比，BD-I 在颞枕区表现出 GMV 的损失，这与情绪处理受损有关。改变的前额-颞-枕网络结构可以反映与 BD-I 中的视觉空间处理和解决问题的障碍以及情绪处理和疾病严重程度相关的神经特征。BD-I 中的结构网络协方差与先前躁狂发作的次数和较差的执行表现有关。与 BD-II 相比，BD-I 在颞枕区表现出 GMV 的损失，这与情绪处理受损有关。改变的前额-颞-枕网络结构可以反映与 BD-I 中的视觉空间处理和解决问题的障碍以及情绪处理和疾病严重程度相关的神经特征。BD-I 中的结构网络协方差与先前躁狂发作的次数和较差的执行表现有关。与 BD-II 相比，BD-I 在颞枕区表现出 GMV 的损失，这与情绪处理受损有关。改变的前额-颞-枕网络结构可以反映与 BD-I 中的视觉空间处理和解决问题的障碍以及情绪处理和疾病严重程度相关的神经特征。