Packed red blood cell (PRBC) transfusions are commonly administered in pediatric patients following the Norwood operation. This study was conducted to determine the effect of PRBC transfusions on hemodynamic parameters in pediatric patients with single-ventricle physiology and parallel circulation. A single-center, retrospective chart review was conducted. Pediatric patients admitted to the cardiac intensive care unit after Norwood operation between 2017 and 2018 were identified. Hemodynamic parameters were collected within a four-hour period before and after a PRBC transfusion. Univariate analyses using paired t tests were conducted to compare blood gas values before and after PRBC transfusion. Next, multivariate regression analyses were conducted to model the impact of transfusion volume, change in hemoglobin levels, and change in FiO2 on the change in PaO2 and PaCO2. These analyses included data from 33 eligible patients who received a PRBC transfusion following a Norwood operation. The hemoglobin levels (p < 0.01) and the PaO2/FiO2 ratio (p = 0.04) were significantly increased, while arterial lactate levels (p = 0.03) were significantly decreased following the transfusion. Transfusion for a pre-transfusion hemoglobin of 12.4 g/dL appears to provide greatest reduction in lactate, used as a surrogate marker for systemic oxygen delivery. No significant changes were found in arterial pH, PaO2, and PaCO2. PRBC transfusions following the Norwood operation may be a useful intervention to increase systemic oxygen delivery, improving PaO2/FiO2 ratio and improving serum lactate. The benefits of PRBC transfusions must be weighed against previously identified risks on a patient-specific basis. Further studies are warranted to further delineate the effects of such transfusions in this population.

在 Norwood 手术后，儿科患者通常会输注浓缩红细胞 (PRBC)。本研究旨在确定 PRBC 输注对单心室生理和平行循环儿科患者血流动力学参数的影响。进行了单中心回顾性图表审查。确定了 2017 年至 2018 年间在诺伍德手术后入住心脏重症监护病房的儿科患者。在 PRBC 输血前后的 4 小时内收集血流动力学参数。使用配对t进行单变量分析进行了测试以比较 PRBC 输血前后的血气值。接下来，进行多变量回归分析，模拟输血量、血红蛋白水平变化和 FiO2 变化对 PaO2 和 PaCO2 变化的影响。这些分析包括来自 33 名符合条件的患者的数据，这些患者在 Norwood 手术后接受了 PRBC 输血。血红蛋白水平 ( p  < 0.01) 和 PaO2/FiO2 比值 ( p  = 0.04) 显着增加，而动脉乳酸水平 ( p = 0.03) 输血后显着降低。输血前血红蛋白为 12.4 g/dL 似乎可以最大程度地降低乳酸，用作全身氧输送的替代标志物。动脉 pH、PaO2 和 PaCO2 未发现显着变化。Norwood 手术后输注 PRBC 可能是增加全身氧气输送、改善 PaO2/FiO2 比率和改善血清乳酸的有用干预措施。PRBC 输血的益处必须根据患者特定情况与先前确定的风险进行权衡。需要进一步的研究来进一步描述这种输血对这一人群的影响。