Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd³⁺ and RB of the as prepared probe are calculated to be 8.2% and 12.5%. The quantum yield of the probe is about 8.84% as well as red fluorescent emissive. The longitudinal r1 value is 6.94 mM^-1 s^-1 and the ratio r2/r1 is very low and about 1.22. Subsequently, the and MR imaging and fluorescence both in vitro and In Vivo are performed. The metabolic pathways In Vivo are inferred by studying the bio-distribution of the probe in major organs. The as-prepared probe exhibits excellent imaging performance and biocompatibility, which is conducive to its further application.

中文翻译：

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用于体内荧光和磁共振双峰成像的红色荧光发光 Gd-酚醛纳米颗粒。

由于荧光成像的高分辨率和磁共振成像穿透深度的无限制的结合，磁共振和荧光双模成像（MR/FI）近年来引起了广泛的研究。在此，通过将罗丹明荧光团共价连接到 Gd-酚类配位聚合物纳米粒子的表面，可以轻松制造出一种新型的 MR/FI 双峰成像探针。所制备的探针的Gd ³⁺和RB含量计算为8.2%和12.5%。探针的量子产率约为 8.84%，并且发射红色荧光。纵向 r1 值为 6.94 mM ^-1 s ^-1并且比率 r2/r1 非常低，约为 1.22。随后，磁共振成像和荧光进行体外和体内。通过研究探针在主要器官中的生物分布来推断体内代谢途径。所制备的探针具有优异的成像性能和生物相容性，有利于其进一步应用。