As a biocompatible and biodegradable polymer, poly(lactide-co-glycolide) (PLGA) has been widely used as a carrier to achieve controlled drug delivery in various forms. Focusing on skin tumor treatment, herein 5-fluorouracil (5-FU) was embedded into the core of coaxially electrospun PLGA fibers to get a drug-loaded core–shell fibrous membrane. In the coaxial electrospinning, poly(vinylpyrrolidone) was applied in the inner flow to facilitate the formation of the core–shell structured fibers. The morphology and micro-structure of the fibers were characterized by scanning electron microscope and transmission electron microscope. The influences of the molecular weights and chemical compositions of PLGA copolymers on the release behaviors were studied. The cytotoxicity of the fibers was characterized by cell proliferation and living-dead cell staining experiments. The results showed that faster release rates would be obtained if the copolymers were of lower molecular weights and higher fraction of glycidyl unit. All the prepared 5-FU loaded fibrous membranes were non-cytotoxic, suggesting their potential applications in skin tumor treatment.

作为一种生物相容性和可生物降解的聚合物，聚（丙交酯-乙交酯）（PLGA）已被广泛用作载体，以实现各种形式的受控药物递送。针对皮肤肿瘤治疗，本文将 5-氟尿嘧啶 (5-FU) 嵌入同轴电纺 PLGA 纤维的核心，得到载药核壳纤维膜。在同轴静电纺丝中，聚（乙烯基吡咯烷酮）被应用于内部流动，以促进核壳结构纤维的形成。采用扫描电镜和透射电镜对纤维的形貌和微观结构进行了表征。研究了PLGA共聚物的分子量和化学成分对释放行为的影响。纤维的细胞毒性通过细胞增殖和活死细胞染色实验来表征。结果表明，如果共聚物具有较低的分子量和较高的缩水甘油基单元分数，将获得较快的释放速率。所有制备的 5-FU 负载纤维膜均无细胞毒性，表明它们在皮肤肿瘤治疗中的潜在应用。