INTRODUCTION Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients. METHODS This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia. RESULT Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40-11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37-22.25%). CONCLUSION This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.

中文翻译：

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埃塞俄比亚艾滋病毒/艾滋病患者血小板减少症和白细胞减少症的患病率：系统评价和荟萃分析。


简介 血小板减少症和白细胞减少症是艾滋病毒/艾滋病感染者中经常遇到的血液系统疾病。这项系统评价和荟萃分析旨在表明全国艾滋病毒/艾滋病患者中血小板减少症和白细胞减少症的患病率。方法 本系统评价和荟萃分析是按照系统评价和荟萃分析 (PRISMA) 指南的首选报告项目进行的。使用电子数据库 Google Scholar、PubMed、Web of Sciences、Google、EMBASE、SCOPUS 和 ResearchGate 于 2021 年 2 月 1 日至 2021 年 4 月 2 日进行了系统检索。使用适用于横断面研究的纽卡斯尔-渥太华质量评估量表（NOS）评估纳入研究的质量。数据分析是使用 STATA 版本 14 使用metan 命令完成的。使用随机效应荟萃分析来估计埃塞俄比亚艾滋病毒/艾滋病患者中血小板减少症和白细胞减少症的汇总患病率。结果 在最初检索的 349 篇文章中，有 90 篇进行了资格评估，只有 2014 年至 2020 年发表的 13 篇文章被纳入最终的荟萃分析。纳入研究共有 3854 名参与者。血小板减少症的汇总患病率为 9.69% (95%CI; 7.40-11.97%)。观察到显着的异质性，I2 值为 84.7%。在未接受过HAART治疗和暴露于HAART治疗的HIV/AIDS患者中，血小板减少症的发生率分别为11.91%和5.95%。 HIV/AIDS 患者中白细胞减少症的汇总患病率为 17.31%（95%CI：12.37-22.25%）。 结论 这项研究显示艾滋病毒/艾滋病患者中血小板减少症和白细胞减少症的患病率较高，表明有必要定期筛查艾滋病毒血清阳性患者的不同血液学参数并提供治疗。