BACKGROUND Brain abscess can be life-threatening and manifest various neurological findings, although the mortality rate has decreased recently. We investigated the risk factors for unfavorable outcomes of patients with brain abscess. METHODS A retrospective cohort study examined patients with brain abscess seen from May 2005 to December 2018 in a tertiary care hospital in Seoul, South Korea. We reviewed the medical records for clinical findings, therapeutic modalities, and prognostic factors of brain abscess. Unfavorable clinical outcomes were defined as death, moderate to severe disability with neurological deficits, or vegetative state at 1 year or at the time of discharge from outpatient follow-up. RESULTS The study enrolled 135 patients: 65.2% were males; the mean age was 56 years. 35.6% had unfavorable outcomes. In multivariate analysis, higher Sequential Organ Failure Assessment (SOFA) (p < 0.001), pre-existing hemiplegia (p = 0.049), and higher Charlson comorbidity index (CCI) (p = 0.028) were independently associated with unfavorable outcomes. CONCLUSIONS Higher SOFA, pre-existing hemiplegia and higher Charlson comorbidity index were significant risk factors for unfavorable clinical outcomes in patients with brain abscess.

中文翻译：

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韩国脑脓肿患者不良临床结局的危险因素。

背景脑脓肿可能危及生命并表现出各种神经学表现，尽管最近死亡率有所下降。我们调查了脑脓肿患者不良结局的危险因素。方法 一项回顾性队列研究检查了 2005 年 5 月至 2018 年 12 月在韩国首尔一家三级医院发现的脑脓肿患者。我们回顾了病历，了解脑脓肿的临床发现、治疗方式和预后因素。不利的临床结果被定义为死亡、中度至重度残疾伴神经功能缺损，或在 1 年或门诊随访出院时出现植物人状态。结果 该研究招募了 135 名患者：65.2% 为男性；平均年龄为56岁。35.6% 有不利的结果。在多元分析中，较高的序贯器官衰竭评估 (SOFA) (p < 0.001)、预先存在的偏瘫 (p = 0.049) 和较高的 Charlson 合并症指数 (CCI) (p = 0.028) 与不利的结果独立相关。结论 较高的 SOFA、先前存在的偏瘫和较高的 Charlson 合并症指数是脑脓肿患者临床预后不良的重要危险因素。