Precise cochlear neuronal development is vital to hearing ability. Understanding the developmental process of the spiral ganglion is useful for studying hearing loss aimed at aging or regenerative therapy. Although interspecies differences have been reported between rodents and humans, to date, most of our knowledge about the development of cochlear neuronal development has been obtained from rodent models because of the difficulty in using human fetal samples in this field. In this study, we investigated cochlear neuronal development in a small New World monkey species, the common marmoset (Callithrix jacchus). We examined more than 25 genes involved in the neuronal development of the cochlea and described the critical developmental steps of these neurons. We also revealed similarities and differences between previously reported rodent models and this primate animal model. Our results clarified that this animal model of cochlear neuronal development is more similar to humans than rodents and is suitable as an alternative for the analysis of human cochlear development. The time course established in this report will be a useful tool for studying primate-specific neuronal biology of the inner ear, which could eventually lead to new treatment strategies for human hearing loss.

中文翻译：

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非人类灵长类动物模型耳蜗的神经元发育，普通狨猴

精确的耳蜗神经元发育对听力至关重要。了解螺旋神经节的发育过程对于研究针对衰老或再生治疗的听力损失很有用。尽管已经报道了啮齿动物和人类之间的种间差异，但迄今为止，由于在该领域使用人类胎儿样本的困难，我们对耳蜗神经元发育发育的大部分知识都是从啮齿动物模型中获得的。在这项研究中，我们调查了一种小型新世界猴种——普通狨猴（Callithrix jacchus ）的耳蜗神经元发育。）。我们检查了超过 25 个参与耳蜗神经元发育的基因，并描述了这些神经元的关键发育步骤。我们还揭示了先前报道的啮齿动物模型和这种灵长类动物模型之间的异同。我们的研究结果表明，这种耳蜗神经元发育的动物模型比啮齿动物更类似于人类，适合作为人类耳蜗发育分析的替代方法。本报告中建立的时间进程将成为研究灵长类动物内耳特异性神经元生物学的有用工具，最终可能导致人类听力损失的新治疗策略。