Objectives

Non-typhoid Salmonella infection is a major agent of food-borne outbreaks as well as individual cases worldwide. However, few studies on drug-resistant Salmonella strains, especially those recovered from young children, are available. Therefore, we determined the prevalence and characteristics of cephalosporin-resistant Salmonella isolates in the south-west region of Korea over a five-year period.

Methods

Non-duplicate Salmonella clinical isolates were recovered from diarrhoeagenic patient specimens at 12 hospitals in Gwangju, Korea between January 2014 and December 2018. Antimicrobial susceptibility testing and molecular features of cephalosporin-resistant isolates were determined.

Results

A total of 652 Salmonella isolates were collected and 48 cefotaxime-resistant Salmonella isolates (7.4%), that belonged to nine Salmonella serovars, were identified. These were S. Enteritidis, S. Typhimurium, S. I 4,[5],12:i:-, S. Virchow, S. Agona, S. Bareilly, S. Infantis, S. Newport, and S. Schleissheim. The prevalence rate increased from 5.3% in 2014 to 10.3% in 2018. S. Virchow (44.4%) showed significantly high resistant rate compared to the other serovars. PGFE genotyping revealed high genetic homogeneities among each Salmonella serovars, suggesting clonal dissemination of cephalosporin-resistant strains.

Conclusions

Progressive increases in carriage rates and the possibility of community outbreaks by cephalosporin-resistant Salmonella in young children may pose tangible public health threats.

中文翻译：

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韩国光州儿童肠道沙门氏菌分离株 ESBLs 和 PABLs 趋势：2014-2018

目标

非伤寒沙门氏菌感染是全球食源性疾病以及个别病例的主要病原体。然而，很少有关于耐药沙门氏菌菌株的研究，尤其是那些从幼儿身上回收的菌株。因此，我们确定了 5 年期间韩国西南部地区耐头孢菌素沙门氏菌分离株的流行情况和特征。

方法

2014 年 1 月至 2018 年 12 月期间，在韩国光州的 12 家医院从腹泻患者标本中回收了非重复的沙门氏菌临床分离株。确定了头孢菌素耐药分离株的抗菌药敏试验和分子特征。

结果

共收集到652株沙门氏菌，鉴定出48株对头孢噻肟耐药的沙门氏菌（7.4%），属于9个沙门氏菌血清型。这些是肠炎沙门氏菌，S。鼠伤寒，S。我 4,[5],12:i:-, S。维尔乔，S . 阿戈纳，S . 巴雷利，S。婴儿，S。纽波特和S。施莱斯海姆。患病率从 2014 年的 5.3% 上升到 2018 年的 10.3% 。与其他血清型相比，Virchow (44.4%) 的耐药率明显较高。PGFE 基因分型揭示了每个沙门氏菌血清型之间的高度遗传同质性，表明头孢菌素耐药菌株的克隆传播。

结论

携带率的逐渐增加以及幼儿中耐头孢菌素沙门氏菌在社区爆发的可能性可能会构成切实的公共卫生威胁。