Cancer, a disease of unknown origin is the second most common reason of death worldwide after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy is the only approach for delivering anti-cancer drugs but shows severe systemic toxicities such as alopecia, loss of appetite, anemia, gastric irritation, neurotoxicity and nephrotoxicity. Additionally, chemotherapeutics fails to achieve the expected therapeutic outcome due to their limited solubility, in-vivo instability and lack of targeting efficiency. Encapsulating drugs in metallic nanoparticles like gold, silver and metal oxides (magnetic) help to overcome limitations of chemotherapy and transports anti-cancer drugs effectively at the targeted site due to the advantages such as optimal size, surface morphology, higher conductivity and in-vivo stability. Moreover, these metals can be triggered externally using NIR radiations or magnetic field thereby improving the drug release kinetics. Some frequently used chemotherapeutic agents such as doxorubicin, paclitaxel, methotrexate, etc. degrade rapidly due to their hydrophobic nature and show in-vivo instability. Cyclodextrin offers structural compatibility for encapsulating such hydrophobic drugs and improves their loading capacity, solubility and stability without showing any systemic toxicities. Therefore, researchers designed cyclodextrin-complexed metallic nanoparticles as a novel platform to overcome pitfalls of conventional chemotherapy like gastric irritation, hair loss, neurotoxicity, etc. This review article provides detail insight of metallic nanocarriers containing cyclodextrin-encapsulated anti-cancer agents for effective cancer therapy. It can be concluded that this novel approach holds a great potential for clinical application in cancer diagnosis, treatment with minimum toxicity and maximum efficacy.

癌症是一种来源不明的疾病，是仅次于心脏病发作的全球第二大常见死亡原因，因此对人类构成重大威胁。目前，化疗是递送抗癌药物的唯一方法，但显示出严重的全身毒性，例如脱发、食欲不振、贫血、胃刺激、神经毒性和肾毒性。此外，化疗药物由于其溶解度有限、体内不稳定性和缺乏靶向效率而未能达到预期的治疗效果。将药物封装在金、银和金属氧化物（磁性）等金属纳米粒子中，由于具有最佳尺寸、表面形态、更高的导电性和体内等优点，有助于克服化疗的局限性，并在目标部位有效地运输抗癌药物稳定。而且，这些金属可以使用 NIR 辐射或磁场从外部触发，从而改善药物释放动力学。一些常用的化疗药物，如阿霉素、紫杉醇、甲氨蝶呤等，由于其疏水性，会迅速降解，并表现出体内不稳定性。环糊精为封装此类疏水性药物提供了结构相容性，并提高了它们的负载能力、溶解性和稳定性，而不会显示出任何全身毒性。因此，研究人员设计了环糊精复合金属纳米粒子作为一种新平台，以克服常规化疗的陷阱，如胃刺激、脱发、神经毒性等。这篇综述文章详细介绍了含有环糊精包封抗癌剂的金属纳米载体，可有效治疗癌症治疗。