Background

Acute mountain sickness (AMS) may cause life-threatening conditions. This study aimed to screen echocardiographic parameters at sea level (SL) to identify predictors of AMS development.

Methods

Overall, 106 healthy men were recruited at SL and ascended to 4100 m within 7 days by bus. Basic characteristics, physiological data, and echocardiographic parameters were collected both at SL and 4100 m above SL. AMS was identified by 2018 Lake Louise Questionnaire Score.

Results

After acute high altitude exposure (AHAE), 33 subjects were diagnosed with AMS and exhibited lower lateral mitral valve tissue motion annular displacement (MV TMAD_lateral) at SL than AMS-free subjects (13.09 vs. 13.89 mm, p = 0.022). MV TMAD_lateral at SL was significantly correlated with AMS occurrence (OR = 0.717, 95% CI: 0.534–0.964, p = 0.028). The MV TMAD_lateral<13.30-mm group showed over 4-fold risk for AMS development versus the MV TMAD_lateral≥13.30-mm group. After AHAE, the MV TMAD_lateral<13.30-mm group had increased HR (64 vs. 74 bpm, p = 0.001) and right-ventricular myocardial performance index (0.54 vs. 0.69, p = 0.009) and decreased left ventricular global longitudinal strain (−21.50 vs. −20.23%, p = 0.002), tricuspid valve E/A ratio (2.11 vs. 1.89, p = 0.019), and MV E-wave deceleration time (169.60 vs. 156.90 ms, p = 0.035).

Conclusion

MV TMAD_lateral at SL was a potential predictor of AMS occurrence and might be associated with differential alterations of ventricular systolic and diastolic functions in subjects with different MV TMAD_lateral levels at SL after AHAE.

中文翻译：

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一种新的超声心动图参数，用于识别易患急性高山病的个体

背景

急性高山病 (AMS) 可能会导致危及生命的疾病。本研究旨在筛选海平面 (SL) 的超声心动图参数，以确定 AMS 发展的预测因素。

方法

总体而言，在 SL 招募了 106 名健康男性，并在 7 天内乘公共汽车上升到 4100 m。在 SL 和 SL 以上 4100 m 处收集基本特征、生理数据和超声心动图参数。AMS 由 2018 年路易斯湖问卷评分确定。

结果

急性高海拔暴露 (AHAE) 后，33 名受试者被诊断出患有 AMS，并且在 SL 处表现出较低的外侧二尖瓣组织运动环位移 (MV TMAD_横向) 比无 AMS 受试者 (13.09 对 13.89 毫米，p = 0.022)。SL 处的MV TMAD_横向与 AMS 的发生显着相关（OR = 0.717，95% CI：0.534–0.964，p = 0.028）。所述MV TMAD_横向<13.30毫米组显示为AMS发展相对于MV TMAD超过4倍的风险_横向≥13.30毫米组。AHAE 后，MV TMAD_外侧<13.30 毫米组 HR（64 对 74 bpm，p = 0.001）和右心室心肌性能指数（0.54 对 0.69，p = 0.009）增加，左心室整体纵向应变降低（-21.50 对 -20.23 %，p = 0.002）、三尖瓣 E/A 比（2.11 对 1.89，p = 0.019）和 MV E 波减速时间（169.60 对 156.90 毫秒，p = 0.035）。

结论

SL 处的MV TMAD_横向是 AMS 发生的潜在预测因子，并且可能与 AHAE后 SL 处具有不同 MV TMAD_横向水平的受试者的心室收缩和舒张功能的差异改变有关。