Diversity of HLA class I and class II alleles in Iran populations: Systematic review and Meta-Analaysis,Transplant Immunology

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Diversity of HLA class I and class II alleles in Iran populations: Systematic review and Meta-Analaysis
Transplant Immunology ( IF 1.5 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.trim.2021.101472
Fateme Abedini ₁ , Narges Rahmanian ₂ , Zahra Heidari ₃ , Awat Feizi ₃ , Roya Sherkat ₄ , Marzieh Rezaei ₅

Affiliation

The human leukocyte antigen (HLA) system plays an essential role in the peptides antigen presentation and more regulation of immune responses. Regarding all HLA molecules' associations with various diseases and their clinical utilities in understanding drug reactions or prediction of transplantation outcome, there is a need for much more extensive HLA data generated from Asian countries.

Method

A comprehensive search was conducted in electronic databases between 1990 and 2021 to identify relevant articles to HLA frequency in the normal Iranian population. Two independent reviewers screened and selected the eligible studies. After data extraction, the meta-analysis was performed using STATA version 14. The overall frequencies and their 95% confidence intervals (CIs) were obtained using the random-effects model.

Results

Among 1141 studies 78 were eligible for this study and the sample sizes varied from 14 to 15,600. The most frequent alleles of HLA class I were HLA-A*02 (22%; 95%CI: 20–24%; I² = 88.63%), -B*35 (18%; 95%CI: 16–21%; I² = 90.95%), -C*12 (18%; 95%CI: 13–22%; I² = 89.51%). HLA-DQA1*01 (42%; 95%CI: 40–44%; I² = 56.80%), -DQB1*03 (38%; 95%CI: 35–42%; I² = 92.38%), and -DRB1*11 (24%; 95%CI: 22–26%; I² = 90.72%) were the most frequent alleles of HLA class II in Iran.

Discussion

Our meta-analysis results point out that the comprehensive report of HLA allele frequency in the Iranian population could be helpful as reference data for planning and managing transplantation and immune disease treatment in Iran.

中文翻译：

伊朗人群中 HLA I 类和 II 类等位基因的多样性：系统评价和元分析

人类白细胞抗原 (HLA) 系统在肽抗原呈递和免疫反应的更多调节中起重要作用。关于所有 HLA 分子与各种疾病的关联及其在了解药物反应或预测移植结果方面的临床效用，需要来自亚洲国家的更广泛的 HLA 数据。

方法

在 1990 年至 2021 年期间，在电子数据库中进行了全面搜索，以确定正常伊朗人群中 HLA 频率的相关文章。两名独立评审员筛选并选择了符合条件的研究。数据提取后，使用 STATA 版本 14 进行荟萃分析。使用随机效应模型获得总体频率及其 95% 置信区间 (CI)。

结果

在 1141 项研究中，78 项符合这项研究的条件，样本量从 14 到 15,600 不等。HLA I 类最常见的等位基因是 HLA-A*02 (22%; 95%CI: 20–24%; I ² = 88.63%), -B*35 (18%; 95%CI: 16–21%) ; I ² = 90.95%), -C*12 (18%; 95%CI: 13–22%; I ² = 89.51%)。HLA-DQA1*01（42%；95%CI：40–44%；I ² = 56.80%），-DQB1*03（38%；95%CI：35–42%；I ² = 92.38%），和-DRB1*11 (24%; 95%CI: 22–26%; I ² = 90.72%) 是伊朗 HLA II 类最常见的等位基因。