Aniline and phenylethylamine react with 4-nitrobenzenesulfonyl chloride in 4% acetone modified supercritical fluid carbon dioxide (SFCO₂) to produce nitro-sulfonamide products via NS bond formation. Solubility measurements of reactants and products in pure SFCO₂ were performed at temperatures 353 K, 363 K, 373 K with pressures ranging from 10 MPa to 20.3 MPa. Aniline exhibits good solubility in SFCO₂ and unlike phenylethylamine does not form a carbamate. Estimates of free phenylethylamine release efficiency from its pre-formed carbamate in SFCO₂ were obtained. Synthetic reactions were performed at 16.8 MPa with temperatures 353 K, 363 K, and 373 K. Under such conditions, on-line SFC reaction progress monitoring established phenylethylamine effectively reacted as a free base at approximately four times the rate of aniline. Nitro-sulfonamide product yields were 75–82.6% using phenylethylamine and 53.9–70.2% using aniline. Aniline product yields were lower due to by-product formation. This study involved using two different interchangeable on-line SFC interfaces.

苯胺和苯乙胺与4-硝基苯磺酰氯反应在4％丙酮改性的超临界流体二氧化碳（SF CO ₂），以产生硝基-磺酰胺产物经由Ñ S键的形成。反应物和产物在纯 SF CO ₂中的溶解度测量在 353 K、363 K、373 K 和 10 MPa 至 20.3 MPa 的压力下进行。苯胺在 SF CO _{2 中}表现出良好的溶解性，并且与苯乙胺不同，不会形成氨基甲酸酯。SF CO _{2 中}预先形成的氨基甲酸酯的游离苯乙胺释放效率的估计获得了。合成反应在 16.8 MPa 和 353 K、363 K 和 373 K 的温度下进行。在这种条件下，在线 SFC 反应进程监测确定苯乙胺以游离碱的形式有效反应，反应速率约为苯胺的四倍。使用苯乙胺的硝基磺酰胺产品产率为 75-82.6%，使用苯胺的产率为 53.9-70.2%。由于副产物形成，苯胺产物产率较低。该研究涉及使用两种不同的可互换在线 SFC 接口。