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Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4+ T cells and ameliorates rheumatoid arthritis
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-09-20 , DOI: 10.1002/cti2.1338
Jiahuan Qin 1 , Xia Huang 2 , Naiqi Wang 3 , Pengcheng Zhou 3 , Hao Zhang 4 , Zhian Chen 3 , Kaili Liang 1 , Dongcheng Gong 1 , Qunxiong Zeng 1 , Peng Niu 1 , Anping Chen 2 , Lin Yuan 5 , Zhaohui Yang 6 , Linchong Su 2 , Nan Shen 1, 7 , Jun Deng 1, 7 , Di Yu 1, 3, 4
Affiliation  

The benefit of Se supplementation in rheumatoid arthritis (RA) has been tested in clinical trials, but results remain inconclusive. The objective of this study was to specifically investigate the potential benefit of supranutritional Se by examining human samples from an area with supranutritional Se intake and testing a mouse model of RA.

中文翻译:

超营养硒抑制 ROS 诱导的表达 RANKL 的破骨 CD4+ T 细胞的产生并改善类风湿性关节炎

补充硒对类风湿性关节炎 (RA) 的益处已在临床试验中进行了测试,但结果仍无定论。本研究的目的是通过检查来自超营养硒摄入地区的人体样本并测试 RA 小鼠模型,专门研究超营养硒的潜在益处。
更新日期:2021-09-21
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