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miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-09-21 , DOI: 10.1002/cti2.1321
Maya Fedeli 1, 2 , Mirela Kuka 2, 3 , Annamaria Finardi 4 , Francesca Albano 1 , Valentina Viganò 1 , Matteo Iannacone 2, 3, 5 , Roberto Furlan 4 , Paolo Dellabona 1 , Giulia Casorati 1
Affiliation  

miR-21 is highly expressed in iNKT and activated T cells, but its T-cell autonomous functions are poorly defined. We sought to investigate the role of miR-21 in the development and functions of T and iNKT cells, representing adaptive and innate-like populations, respectively.

中文翻译:

miR-21 以牺牲自身耐受性为代价维持 CD28 信号传导和低亲和力 T 细胞反应

miR-21 在 iNKT 和活化的 T 细胞中高度表达,但其 T 细胞自主功能尚不明确。我们试图研究 miR-21 在 T 和 iNKT 细胞的发育和功能中的作用,分别代表适应性和先天样种群。
更新日期:2021-09-21
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