miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance,Clinical & Translational Immunology

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miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-09-21 , DOI: 10.1002/cti2.1321
Maya Fedeli _{1,

2} , Mirela Kuka _{2,

3} , Annamaria Finardi ₄ , Francesca Albano ₁ , Valentina Viganò ₁ , Matteo Iannacone _{2,

3,

5} , Roberto Furlan ₄ , Paolo Dellabona ₁ , Giulia Casorati ₁

Affiliation

miR-21 is highly expressed in iNKT and activated T cells, but its T-cell autonomous functions are poorly defined. We sought to investigate the role of miR-21 in the development and functions of T and iNKT cells, representing adaptive and innate-like populations, respectively.

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