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Front Cover Picture: Synthesis of Enantioenriched Amines by Iron-Catalysed Amination of Alcohols Employing at Least One Achiral Substrate (Adv. Synth. Catal. 24/2021)
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2021-09-21 , DOI: 10.1002/adsc.202101078
G. Bottari 1 , A. Afanasenko 1 , A. A. Castillo‐Garcia 2 , B. L. Feringa 1 , K. Barta 1, 2
Affiliation  

The Front Cover Picture, designed by Anastasiia Afanasenko, illustrates the methodology for the synthesis of enantioenriched amines by the direct Fe-catalysed coupling of amines with alcohols through the borrowing hydrogen strategy, while at least one of these substrates is achiral. As in the well-known “The Tortoise and the Hare” fable by Aesop, tortoise – stands for chiral amine – won the race retaining the stereochemical integrity in the final product, whereas beta-branched enantioenriched primary alcohol – depicts by the hare – lost the competition due to its racemization that led to the partial loss of the chirality in the target amine. Details can be found in the Research Article by Katalin Barta and collaborators (G. Bottari, A. Afanasenko, A. A. Castillo-Garcia, B. L. Feringa, K. Barta, Adv. Synth. Catal. 2021, 363, 5436–5442; DOI: 10.1002/adsc.202100231).
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中文翻译:

封面图片:使用至少一种非手性底物的醇通过铁催化胺化合成对映体富集胺(Adv. Synth. Catal. 24/2021)

封面图片,通过Anastasiia Afanasenko设计,示出了由用于对映体富集的胺的合成的方法的直接的Fe催化的通过借用氢策略醇胺的偶联,而这些基板中的至少一个是手性的。正如伊索著名的“乌龟和兔子”寓言一样,乌龟——代表手性胺——赢得了比赛,保留了最终产品中立体化学的完整性,而贝塔-支化对映体富集的伯醇——由野兔描述——由于其外消旋化导致目标胺手性的部分丧失而失去了竞争。细节可以在研究论文通过卡塔琳巴塔和合作者(G. Bottari,A. Afanasenko,A.A卡斯蒂略加西亚,B.L。Feringa的,K.巴塔,中找到。进阶Synth的CATAL2021363,5436-5442; DOI: 10.1002/adsc.202100231)。
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更新日期:2021-09-21
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