In Vivo–In Vitro Correlations for the Assessment of Cadmium Bioavailability in Vegetables,Journal of Agricultural and Food Chemistry

当前位置： X-MOL 学术 › J. Agric. Food Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

In Vivo–In Vitro Correlations for the Assessment of Cadmium Bioavailability in Vegetables
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-09-21 , DOI: 10.1021/acs.jafc.1c03284
Yanyan Wei ₁ , Xiaoman Zheng ₁ , Zengyu Zhang ₁ , Huanting Liang ₁ , Minghua Gu ₁ , Fangke Shen ₁ , M J I Shohag ₂ , Xiaofeng Li ₁

Affiliation

The correlation of in vitro and in vivo assays for determining bioavailable Cd amounts in vegetables is limited. Herein, the correlations between Cd relative bioavailability (Cd-RBA) in rat models and Cd bioaccessibility in four in vitro assays were examined in vegetables. Results showed that the combined liver plus kidney data provided the appropriate endpoint and was used as a biomarker to estimate Cd-RBA. The Cd-RBA was negatively correlated with the mole ratio of Ca/Cd and Fe/Cd in vegetables. Strong in vivo–in vitro correlations were found from physiologically based extraction test (PBET) and in vitro gastrointestinal (IVG) (R² = 0.66–0.69). We concluded that PBET and IVG were optimal models for Cd-RBA determination in vegetables. The nutritional elements in the vegetables could affect Cd absorption. Furthermore, the Cd bioavailability in vegetables should be considered because risk estimates solely based on the total Cd concentration in vegetables would overestimate Cd intake.

中文翻译：

评估蔬菜中镉生物利用度的体内-体外相关性

用于确定蔬菜中生物可利用 Cd 量的体外和体内测定的相关性是有限的。在此，在蔬菜中检查了大鼠模型中 Cd 相对生物利用度 (Cd-RBA) 与四种体外测定中Cd 生物可及性之间的相关性。结果表明，肝肾联合数据提供了适当的终点，并被用作估计 Cd-RBA 的生物标志物。Cd-RBA与蔬菜中Ca/Cd和Fe/Cd的摩尔比呈负相关。强在体内外相关性进行了从基于生理学的提取试验（PBET），并发现在体外胃肠（IVG）（- [R ²= 0.66–0.69）。我们得出结论，PBET 和 IVG 是测定蔬菜中 Cd-RBA 的最佳模型。蔬菜中的营养元素会影响Cd的吸收。此外，应考虑蔬菜中镉的生物利用度，因为仅基于蔬菜中镉总浓度的风险估计会高估镉的摄入量。

更新日期：2021-10-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11