Prevention is an attractive solution for the staggering and increasingly unmanageable burden of osteoarthritis. Despite this, the field of osteoarthritis prevention is relatively immature. To date, most of what is known about preventing osteoarthritis and risk factors for osteoarthritis is relative to the disease (underlying biology and pathophysiology) of osteoarthritis, with few studies considering risk factors for osteoarthritis illness, the force driving the personal, financial and societal burden. In this narrative review we will discuss what is known about osteoarthritis prevention, propose actionable prevention strategies related to obesity and joint injury which have emerged as important modifiable risk factors, identify where evidence is lacking, and give insight into what might be possible in terms of prevention by focussing on a lifespan approach to the illness of osteoarthritis, as opposed to a structural disease of the elderly. By targeting a non-specialist audience including scientists, clinicians, students, industry employees and others that are interested in osteoarthritis but who do not necessarily focus on osteoarthritis, the goal is to generate discourse and motivate inquiry which propel the field of osteoarthritis prevention into the mainstream.

预防是解决骨关节炎令人震惊且越来越难以控制的负担的一种有吸引力的解决方案。尽管如此，骨关节炎预防领域还相对不成熟。迄今为止，关于预防骨关节炎和骨关节炎危险因素的大部分知识都与骨关节炎的疾病（基础生物学和病理生理学）有关，很少有研究考虑骨关节炎疾病的危险因素，推动个人、财务和社会负担的力量。在这篇叙述性综述中，我们将讨论关于骨关节炎预防的已知信息，提出与肥胖和关节损伤相关的可操作预防策略，这些策略已成为重要的可改变风险因素，确定缺乏证据的地方，并深入了解可能的情况通过关注疾病的终生方法进行预防骨关节炎，而不是老年人的结构性疾病。通过针对包括科学家、临床医生、学生、行业雇员和其他对骨关节炎感兴趣但不一定关注骨关节炎的非专业受众，目标是产生话语并激发探究，从而推动骨关节炎预防领域进入主流。