Comparison of live birth rates after IVF–embryo transfer with and without preimplantation genetic testing for aneuploidies,Reproductive BioMedicine Online

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Comparison of live birth rates after IVF–embryo transfer with and without preimplantation genetic testing for aneuploidies
Reproductive BioMedicine Online ( IF 3.7 ) Pub Date : 2021-09-21 , DOI: 10.1016/j.rbmo.2021.09.011
Emily Sadecki ₁ , Laura Rust ₂ , David L Walker ₃ , Jolene R Fredrickson ₃ , Anthony Krenik ₃ , Tana Kim ₄ , Amy L Weaver ₅ , Yulian Zhao ₆

Affiliation

Research question

Does the use of preimplantation genetic testing for aneuploidies (PGT-A) result in higher live birth rates when compared with both fresh and frozen embryo transfers (FET) not utilizing PGT-A?

Design

Retrospective cohort study at a single tertiary centre using inverse probability of treatment weighting (IPTW) to adjust for differences in baseline characteristics between groups.

Results

A total of 107 FET using PGT-A from 74 patients, along with 321 fresh and 286 FET not using PGT-A from 381 patients met the inclusion criteria for this study. In the IPTW-adjusted analysis of transfer-level data, PGT-A transfers resulted in a significantly higher live birth rate when compared with both non-PGT-A fresh (49.5% versus 38.6%, P = 0.036) and FET (50.6% versus 35.8%, P = 0.016). When data were analysed per retrieval level, the live birth rate was similar and acceptably high with or without PGT-A (63.7% versus 52.3%, P = 0.09).

Conclusion

When comparing PGT-A to non-PGT-A fresh and FET, PGT-A embryo transfers have a significantly higher live birth rate. However, this difference did not persist at a per-retrieval level. Further investigation is needed to understand in what scenarios PGT-A has clinical significance and whether differences in the number of available embryos for transfer negates the benefit of PGT-A.

中文翻译：

IVF-胚胎移植后的活产率比较，有和没有非整倍体植入前基因检测

研究问题

与不使用 PGT-A 的新鲜和冷冻胚胎移植 (FET) 相比，使用非整倍体植入前基因检测 (PGT-A) 是否会导致更高的活产率？

设计

在一个三级中心进行回顾性队列研究，使用逆概率治疗加权 (IPTW) 来调整组间基线特征的差异。

结果

来自 74 名患者的 107 个使用 PGT-A 的 FET，以及来自 381 名患者的 321 个新鲜和 286 个不使用 PGT-A 的 FET 符合本研究的纳入标准。在转移水平数据的 IPTW 调整分析中，与非 PGT-A 新鲜（49.5% 对 38.6%， P  = 0.036）和 FET（50.6%）相比，PGT-A 转移导致活产率显着提高与 35.8%，P  = 0.016）。当按检索级别分析数据时，无论是否使用 PGT-A，活产率相似且可接受的高（63.7% 对 52.3%，P  = 0.09）。