Abstract

Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits in vivo anti-inflammatory activity.

中文翻译：

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藜芦素作为一种抗炎化合物

摘要

Chenopodin 是一种从藜麦种子中提纯的 11S 型球蛋白，可结合碳水化合物和血凝人红细胞。本研究旨在评估异二聚藜芦丁的 N 端结构及其在炎症模型中的作用。Chenopodin 在其结构上呈现出两个亚基，并且与其他 Chenopodin 具有 92% 的 N 端同源性。Chenopodin 减少了由角叉菜胶诱导的小鼠爪水肿和中性粒细胞募集。最后，我们证明了藜芦素在体内表现出抗炎活性。