Abstract

Two new α-pyrones, micropyrones A (1) and B (2), along with four known γ-pyrones, nocapyrone D (3), nocapyrone A (4), marinactinone A (5), and nocapyrone H (6), were isolated from the culture extract of actinomycete Microbacterium sp. GJ312, which was isolated from Glycyrrhiza uralensis. The structures of these compounds were identified by analysis of spectral data. They are the first α- and γ-pyrones reported from the genus Microbacterium. The antibacterial activity of all compounds against Staphylococcus aureus and methicillin resistant S. aureus was evaluated. However, none of them showed significant activity. This study represents the first phytochemical example of a Glycyrrhiza-derived actinomycete.

摘要

两种新的α -吡喃酮、微吡喃酮 A ( 1 ) 和 B ( 2 )，以及四种已知的γ -吡喃酮、诺卡吡喃酮 D ( 3 )、诺卡吡喃酮 A ( 4 )、marinactinone A ( 5 ) 和诺卡吡喃酮 H ( 6 )，从放线菌微杆菌属的培养物提取物中分离出来。GJ312，从甘草中分离得到。这些化合物的结构是通过光谱数据分析确定的。它们是第一个从微杆菌属中报道的α-和γ-吡喃酮。所有化合物的抗菌活性评估了金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌。然而，它们都没有表现出显着的活性。这项研究代表了甘草衍生放线菌的第一个植物化学实例。