In the article by Redd et al, “Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury,” which published online on July 15, 2021, and appears in the September 21, 2021, issue of the journal (Circulation.2021;144:947–960. DOI: 10.1161/CIRCULATIONAHA.121.054360), a correction is needed.

Di Xia, PhD was mistakenly omitted from the author list. The authors regret this oversight. Di Xia’s contributions to the manuscript were as follows:

Di Xia carried out gene editing on the iPSCs to generate the knockout of ASIC1a shown in Figures 1 as well as Supplemental Figures 2 and 3. The final methods provided for the initial publication acknowledged the Queensland Facility for Advanced Genome Editing for this work. However, the work by Dr Xia was a more substantial intellectual contribution to the study. In particular, the specific gRNAs used for the ASIC1a KO were used in a program of work designed to enhance gene editing efficiency in iPSCs that required major method development partially outlined in Supplemental Figure 3.

Dr Xia’s contribution enabled knockout of >98% of alleles in a single transfection. This level of efficiency enabled efficient progress in the experimental work required for revisions of the manuscript. In particular, this cell line was used to respond to reviewer comments requesting data on cell-specific genetic loss of function to demonstrate that ASIC1a is functionally involved in mediating cardiomyocyte cell death in response to ischemia-reperfusion injury.

Dr Xia provided all methods related to gene editing of ASIC1a knockout iPSCs including the intellectual expertise for maximizing gene editing efficiencies for knockout of ASIC1a.

Dr Xia provides approval of all results, methods, and conclusions of the final publication.

The corrected author list reads as follows:

Meredith A. Redd, PhD; Sarah E. Scheuer, MD; Natalie J. Saez, PhD; Yusuke Yoshikawa, MD, PhD; Han Sheng Chiu, MS; Ling Gao, PhD; Mark Hicks, PhD; Jeanette E. Villanueva, PhD; Yashutosh Joshi, MD; Chun Yuen Chow, PhD; Gabriel Cuellar-Partida, PhD; Jason N. Peart, PhD; Louise E. See Hoe, PhD; Xiaoli Chen, PhD; Yuliangzi Sun, MS; Jacky Y. Suen, PhD; Robert J. Hatch, PhD; Ben Rollo, PhD; Di Xia, PhD; Mubarak A.H. Alzubaidi, PhD; Snezana Maljevic, PhD; Gregory A. Quaife-Ryan, PhD; James E. Hudson, PhD; Enzo R. Porrello, PhD; Melanie Y. White, PhD; Stuart J. Cordwell, PhD; John F. Fraser, MD, PhD; Steven Petrou, PhD; Melissa E. Reichelt, PhD; Walter G. Thomas, PhD; Glenn F. King, PhD; Peter S. Macdonald, MD, PhD; Nathan J. Palpant, PhD

Dr Xia is affiliated with the Genome Innovation Hub, The University of Queensland, St. Lucia, Australia.

The correction has been made to the current online version of the article, which is available at https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054360.

在 Redd 等人的文章中，“Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury”，该文章于 2021 年 7 月 15 日在线发表，并发表在 2021 年 9 月 21 日的期刊（Circulation. 2021;144:947–960. DOI: 10.1161/CIRCULATIONAHA.121.054360)，需要更正。

Di Xia, PhD 被错误地从作者名单中遗漏了。作者对这一疏忽感到遗憾。狄夏对手稿的贡献如下：

Di Xia 对 iPSC 进行了基因编辑，以产生图 1 以及补充图 2 和图 3 中所示的 ASIC1a 基因敲除。为初始出版物提供的最终方法承认昆士兰高级基因组编辑机构对这项工作的认可。然而，夏博士的工作对这项研究做出了更实质性的智力贡献。特别是，用于 ASIC1a KO 的特定 gRNA 用于一项旨在提高 iPSC 中基因编辑效率的工作计划，该计划需要主要方法开发，在补充图 3 中部分概述。

夏博士的贡献在单次转染中敲除 > 98% 的等位基因。这种效率水平使修改手稿所需的实验工作取得了有效进展。特别是，该细胞系被用来回应审稿人的评论，要求提供细胞特异性遗传功能丧失的数据，以证明 ASIC1a 在功能上参与介导心肌细胞死亡，以响应缺血-再灌注损伤。

夏博士提供了与 ASIC1a 敲除 iPSC 基因编辑相关的所有方法，包括最大限度提高 ASIC1a 敲除的基因编辑效率的专业知识。

夏博士对最终出版物的所有结果、方法和结论表示认可。

更正后的作者名单如下：

Meredith A. Redd，博士；Sarah E. Scheuer，医学博士；Natalie J. Saez，博士；Yusuke Yoshikawa，医学博士，博士；邱汉生，硕士；高玲，博士；马克·希克斯博士；Jeanette E. Villanueva 博士；Yashutosh Joshi，医学博士；周俊元，博士；Gabriel Cuellar-Partida，博士；Jason N. Peart，博士；Louise E. See Hoe 博士；陈晓丽，博士；孙玉良子，硕士；Jacky Y. Suen，博士；罗伯特 J. 哈奇博士；本·罗洛，博士；狄霞，博士；Mubarak AH Alzubaidi，博士；Snezana Maljevic，博士；Gregory A. Quaife-Ryan，博士；James E. Hudson，博士；Enzo R. Porrello，博士；Melanie Y. White，博士；Stuart J. Cordwell，博士；John F. Fraser，医学博士，博士；史蒂文彼得鲁，博士；Melissa E. Reichelt，博士；Walter G. Thomas，博士；Glenn F. King，博士；Peter S. Macdonald，医学博士，博士；Nathan J. Palpant 博士

夏博士隶属于澳大利亚圣卢西亚昆士兰大学基因组创新中心。

已对文章的当前在线版本进行更正，该版本可在 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054360 上获得。