Temperature-sensitive hydrogels have shown good performances as wound dressing owing to their ability to fill wounds in the liquid state and to release drugs in a solid state. However, their treatment efficiency is restricted by the phase transition time. In this study, we developed a photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β-GP-MPDA@Cip, with the unique properties of rapid phase transition and drug release under near-infrared light (NIR). High antibacterial efficiency was achieved when we covered infected mice wounds with hydrogels. The local high temperature produced under NIR illumination not only accelerated the formation of a porous gel to release the loaded drug on-demand, but also dissolved bacteria, achieving synergistic anti-bacterial treatment. In addition, the healing cycle of wounds could be significantly shortened by adding human epidermal growth factor (h-EGF) in the hydrogel. Overall, the developed temperature-sensitive hydrogel could utilise NIR as a “trigger switch” for on-demand drug release and photothermal-enhanced antibacterial treatment during the rapid phase change process.

温度敏感水凝胶作为伤口敷料显示出良好的性能，因为它们能够以液态填充伤口并在固态下释放药物。然而，它们的处理效率受到相变时间的限制。在这项研究中，我们开发了一种基于光热协同壳聚糖的温敏水凝胶 h-EGF-CS/ β-GP-MPDA@Cip，在近红外光（NIR）下具有快速相变和药物释放的独特特性。当我们用水凝胶覆盖受感染的小鼠伤口时，实现了高抗菌效率。NIR照射下产生的局部高温不仅加速了多孔凝胶的形成以按需释放负载的药物，而且溶解细菌，实现协同抗菌处理。此外，在水凝胶中添加人表皮生长因子（h-EGF）可以显着缩短伤口的愈合周期。总体而言，开发的温度敏感水凝胶可以利用 NIR 作为“触发开关”，在快速相变过程中进行按需药物释放和光热增强抗菌处理。