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Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China
Genomics ( IF 3.4 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.ygeno.2021.09.006
Yuee Zu 1 , Zhihua Ou 2 , Dan Wu 1 , Wei Liu 3 , Liwen Liu 4 , Di Wu 5 , Yanping Zhao 2 , Peidi Ren 2 , Yanqing Zhang 1 , Wangsheng Li 6 , Shujin Fu 7 , Yongchun Wen 1 , Xianchu Cai 6 , Wenbo Liao 1 , Chunyu Geng 7 , Hongcheng Zhou 6 , Xiaman Wang 8 , Haorong Lu 6 , Huanhuan Peng 8 , Na Liu 8 , Shida Zhu 9 , Jiyang Liu 4 , Dongbo Wang 1 , Junhua Li 3
Affiliation  

Persistent infections of high-risk human papillomaviruses (HPVs) are the leading cause of cervical cancers. We collected cervical exfoliated cell samples from females in Changsha city, Hunan Province and obtained 338 viral genomes of four major HPV types, including HPV 16 (n = 82), 18 (n = 35), 52 (n = 121) and 58 (n = 100). The lineage/sublineage distribution of the four HPVs confirmed previous epidemiological reports, with the predominant prevailing sublineage as A4 (50%), A1 (37%) and A3 (13%) for HPV16, A1 (83%) for HPV18, B2 (86%) for HPV52 and A1 (65%), A3 (19%) and A2 (12%) for HPV58. We also identified two potentially novel HPV18 sublineages, i.e. A6 and A7. Virus mutation analysis further revealed the presence of HPV16 and HPV58 sublineages associated with potentially high oncogenicity. These findings expanded our knowledge of the HPV genetic diversity in China, providing valuable evidence to facilitate HPV DNA screening, vaccine effectiveness evaluation and control strategy development.

更新日期:2021-09-30
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