The mutant βE202K sliding clamp protein impairs DNA polymerase III replication activity,Journal of Bacteriology

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The mutant βE202K sliding clamp protein impairs DNA polymerase III replication activity
Journal of Bacteriology ( IF 2.7 ) Pub Date : 2021-09-20 , DOI: 10.1128/jb.00303-21
Caleb Homiski ₁ , Michelle K Scotland ₁ , Vignesh M P Babu ₁ , Sundari Chodavarapu ₂ , Robert W Maul ₁ , Jon M Kaguni ₂ , Mark D Sutton ₁

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Expression of the E. coli dnaN-encoded β clamp at ≥10-fold higher than chromosomally-expressed levels impedes growth by interfering with DNA replication. We hypothesized that the excess β clamp sequesters the replicative DNA polymerase III (Pol III) to ...

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