Intracellular activity of antibiotics against Coxiella burnetii in a model of activated human THP-1 cells,Antimicrobial Agents and Chemotherapy

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Intracellular activity of antibiotics against Coxiella burnetii in a model of activated human THP-1 cells
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-09-20 , DOI: 10.1128/aac.01061-21
Frédéric Peyrusson ₁ , Adam O Whelan ₂ , Margaret G Hartley ₂ , Isobel H Norville ₂ , Sarah V Harding ₂ , Françoise Van Bambeke ₁

Affiliation

We evaluated antibiotic activity against the intracellular bacterium Coxiella burnetii using an activated THP-1 cell model of infection. At clinically-relevant concentrations, the intracellular bacterial load was reduced 300-fold by levofloxacin and ...

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