Linezolid population pharmacokinetics in South African adults with drug-resistant tuberculosis.,Antimicrobial Agents and Chemotherapy

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Linezolid population pharmacokinetics in South African adults with drug-resistant tuberculosis.
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-09-20 , DOI: 10.1128/aac.01381-21
Mahmoud Tareq Abdelwahab ₁ , Sean Wasserman _{1,

2,

3} , James C M Brust ₄ , Keertan Dheda _{5,

6,

7} , Lubbe Wiesner ₁ , Neel R Gandhi _{8,

9} , Robin M Warren ₁₀ , Frederick A Sirgel ₁₀ , Graeme Meintjes ₂ , Gary Maartens _{1,

2} , Paolo Denti ₁

Affiliation

Division of Clinical Pharmacology, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York, USA.
Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, Cape Town, South Africa.
South African Medical Research Council Centre for the Study of Antimicrobial Resistance, University of Cape Towngrid.7836.a, Cape Town, South Africa.
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Departments of Epidemiology and Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Division of Infectious Diseases, Department of Medicine, Emory School of Medicine, Emory University, Atlanta, Georgia, USA.
DST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Stellenbosch, South Africa.

BACKGROUNDLinezolid is widely used for drug-resistant tuberculosis (DR-TB) but has a narrow therapeutic index. To inform dose optimisation, we aimed to characterise the population pharmacokinetics of linezolid in South African participants with DR-TB and ...

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