Sepsis is a complex disease stemming from a dysregulated immune response toward an infectious agent. In transplantation, sepsis remains one of the leading causes of morbidity and mortality. Solid organ transplant recipients have impaired adaptive immunity due to immunosuppression required to prevent rejection. Immunosuppression has unintended consequences, such as increasing the risk of infections and sepsis. Due to its high morbidity and mortality, early detection of sepsis is paramount to start aggressive treatment. Several biomarkers or combination of biomarkers of sepsis have emerged in the last decade, but they are not dependable for early diagnosis or for outcome prognosis.

脓毒症是一种复杂的疾病，源于对传染原的免疫反应失调。在移植中，败血症仍然是发病率和死亡率的主要原因之一。由于防止排斥反应所需的免疫抑制，实体器官移植受者的适应性免疫受损。免疫抑制会产生意想不到的后果，例如增加感染和败血症的风险。由于其高发病率和死亡率，早期发现败血症对于开始积极治疗至关重要。在过去的十年中出现了几种脓毒症的生物标志物或生物标志物的组合，但它们对于早期诊断或结果预后并不可靠。